基于惯性测量器件的无线步态分析平台

步态定量测量方法应用于许多领域,如临床医学、双足机器人控制等.采用惯性测量单元结合无线传感器网络建立了一个步态分析平台,将两个无线惯性测量单元传感器节点分别绑定在左右双侧脚踝,以同时采集双脚运动过程中的加速度和角速度信号,并将其通过无线方式发送到远程终端.通过模式识别、时间序列分析、阈值检测和零速修正等多种数据融合方法计算步态参数,并通过融合双足传感器数据得到双支撑相、双脚步行周期等重要的双足步态参数,其中双支撑相参数对人体日常动作的识别有重要意义.实验结果显示该研究具有较高的计算精度.     

改进粒子群算法的自动阻抗匹配技术

由于无线电能传输距离的改变或谐振线圈之间发生偏移、负载改变等多方面的影响使系统的输入阻抗发生变化,导致输入阻抗与射频源内阻不匹配,使传输效率大幅下降。在射频源和发射线圈之间加入阻抗匹配网络可以提高无线电能的传输效率。为了提高阻抗匹配的精度和速度,提出了一种改进的粒子群算法。重点将改进算法和传统算法进行仿真实验比较,证明了改进算法在匹配精度和速度方面的优越性。最后将该算法嵌入到自动阻抗匹配系统中,提高了无线电能的传输效率,同时证明了所提算法的有效性。     

多目标博弈问题的求解算法

针对多个局中人多个支付函数的多目标博弈问题,研究每个局中人支付函数均衡协调最优值的存在性.证明了博弈系统在均衡协调意义下均衡解的存在性,并给出了求解多目标博弈问题的均衡协调算法.实例分析检验了算法的合理性和有效性.     

人工蜂群算法及其应用

为促进人工蜂群算法理论和应用的发展, 在分析人工蜂群算法的基本原理基础上, 针对算法的不足, 全面地归纳了国内外学者对算法的改进研究, 对算法的蜜源初始化、更新策略的改进、调整策略的改进、适应度函数的选择以及与其他算法的融合进行综述, 提出了更有效的改进策略。同时从多方面综述了人工蜂群算法的应用, 并对人工蜂群算法的发展方向进行了总结和展望。     

MTMR14基因缺失促进小鼠成肌细胞增殖和分化

为研究磷酸肌醇磷酸酶肌管相关蛋白14(MTMR14)在骨骼肌发生中的作用,通过组织切片和细胞培养技术研究了MTMR14敲除对骨骼肌的组织结构、成肌细胞分化和增殖的影响.结果表明:MTMR14敲除小鼠的腓肠肌和比目鱼肌的结构较同窝野生型小鼠产生了明显变化,MTMR14敲除小鼠的成肌细胞的分化和增殖成肌小管过程较野生型显著加快.MTMR14基因敲除后小鼠肌管细胞中平均细胞核数显著增加.故MTMR14基因缺失/敲除导致骨骼肌组织结构异常,干扰了骨骼肌肌肉发生过程中的成肌细胞的增殖和分化.     

触摸式远程控制终端设计

设计的触摸式远程控制终端由主控制端和从控制端2部分所组成,硬件结构包括STM32处理器、TFT触摸屏、CAN总线、n RF24L01模块、串口通信模块和电源模块。利用Keil MDK-ARM 5实现终端软件的开发,CAN总线通信网络进行数据通讯,n RF24L01无线通讯进行指令传输。实验结果表明,触摸式远程控制终端能够可靠传输数据,快速响应远程操作。     

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Calorie restriction extends lifespan and produces a metabolic profile desirable for treating diseases of ageing such as type 2 diabetes. SIRT1, an NAD+-dependent deacetylase, is a principal modulator of pathways downstream of calorie restriction that produce beneficial effects on glucose homeostasis and insulin sensitivity. Resveratrol, a polyphenolic SIRT1 activator, mimics the anti-ageing effects of calorie restriction in lower organisms and in mice fed a high-fat diet ameliorates insulin resistance, increases mitochondrial content, and prolongs survival. Here we describe the identification and characterization of small molecule activators of SIRT1 that are structurally unrelated to, and 1,000-fold more potent than, resveratrol. These compounds bind to the SIRT1 enzyme-peptide substrate complex at an allosteric site amino-terminal to the catalytic domain and lower the Michaelis constant for acetylated substrates. In diet-induced obese and genetically obese mice, these compounds improve insulin sensitivity, lower plasma glucose, and increase mitochondrial capacity. In Zucker fa/fa rats, hyperinsulinaemic-euglycaemic clamp studies demonstrate that SIRT1 activators improve whole-body glucose homeostasis and insulin sensitivity in adipose tissue, skeletal muscle and liver. Thus, SIRT1 activation is a promising new therapeutic approach for treating diseases of ageing such as type 2 diabetes.     

Structural definition of a conserved neutralization epitope on HIV-1 gp120

The remarkable diversity, glycosylation and conformational flexibility of the human immunodeficiency virus type 1 (HIV-1) envelope (Env), including substantial rearrangement of the gp120 glycoprotein upon binding the CD4 receptor, allow it to evade antibody-mediated neutralization. Despite this complexity, the HIV-1 Env must retain conserved determinants that mediate CD4 binding. To evaluate how these determinants might provide opportunities for antibody recognition, we created variants of gp120 stabilized in the CD4-bound state, assessed binding of CD4 and of receptor-binding-site antibodies, and determined the structure at 2.3 A resolution of the broadly neutralizing antibody b12 in complex with gp120. b12 binds to a conformationally invariant surface that overlaps a distinct subset of the CD4-binding site. This surface is involved in the metastable attachment of CD4, before the gp120 rearrangement required for stable engagement. A site of vulnerability, related to a functional requirement for efficient association with CD4, can therefore be targeted by antibody to neutralize HIV-1.